Position: MSc Student
Michał Sadowski interests are from the field of physics and genome biology and are presently focused on genome architecture, genome organization and their link to gene regulation. These areas of study can be explored by an analysis of data coming from experimental methods which capture chromatin conformation both locally (3C, 4C) and genome-wide (Hi-C and ChIA-PET). This analysis can lead us to better understanding of gene expression mechanisms and provide a new insight into relation between gene expression and genomic variation. In his present work Michał Sadowski is trying to combine conformation capture data, genomic variation data and gene transcription data, in order to pursue more complete explanation of gene regulation processes, genome spatial arrangement and its evolution.
Publications in lab:
3D-GNOME 2.0: a three-dimensional genome modeling engine for predicting structural variation-driven alterations of chromatin spatial structure in the human genome.
(Nucleic Acids Res.) [Pub Med ID: 32442297]
Spatial chromatin architecture alteration by structural variations in human genomes at the population scale.
(Genome Biol.) [Pub Med ID: 28406212]
An integrated 3-Dimensional Genome Modeling Engine for data-driven simulation of spatial genome organization.
(Genome Res.) [Pub Med ID: 27789526]